Depending on your configuration and your use of Guardian you are running it is quite possible you are running out of windows resources. This can be even more evident if you try to run multiple instances.
This is a windows issue and occurs regardless of the PC it’s running on.
Every label, text box, image, picklist, icon etc uses a Windows resource and it’s very easy to use them all up.
If you are not using certain functions or screens in Bet Angel then it is worth hiding them using the "Features" menu and then "Save Settings". Reboot your PC and restart Bet Angel and it will use less resources as is won’t initialise the hidden screens.